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Platelet-Rich Plasma (PRP) Research

Use of Platelet-Rich Plasma and Hyaluronic Acid in the Loss of Substance with Bone Exposure

In lower-extremity surgery, the complex wound with bone exposure remains a challenging problem for the plastic surgeon. The purpose of this study was to describe a new therapeutic approach to stimulate the regeneration of the lower-extremity complex wounds based on a combined treatment composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) dressing.

DESIGN: Wounds with posttraumatic bone exposure have been treated with HA dressing alone or in combination with PRP.

PATIENT: Fifteen patients affected by lower-extremity wound with posttraumatic bone exposure have been treated at the Department of Plastic and Reconstructive Surgery, University of Tor Vergata, Rome, Italy.

RESULTS: After a single treatment, the authors observed that the mean re-epithelialization time was 8.1 weeks in 73.3% patients treated with PRP and HA dressing versus the 30% patients treated with HA dressing only.

CONCLUSION: These data confirm the evidence of using PRP technology in the healing of both soft- and hard-tissue wounds. Moreover, the satisfaction of the patient confirms the quality of this study’s results. READ MORE

Use of cell fat mixed with platelet gel in progressive hemifacial atrophy.

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome, is an uncommon degenerative and poorly understood condition. It is characterized by a slow and progressive atrophy affecting one side of the face. The incidence and cause of this alteration are unknown, and the pathogenesis of the syndrome is not clear. Some authors attribute the atrophy of the subcutaneous system to an alteration of the sympathetic system. Others attribute it to an alteration of the nervous system at the encephalic level or to an interstitial neuritis of the trigeminal nerve. The most common complications that appear in association with this disorder are trigeminal neuritis, facial disorders, and epilepsy. The latter is the most frequent complication of the central nervous system. Characteristically, the atrophy progresses slowly for several years and soon becomes stable. After stabilization of the disease, plastic surgery of autogenous fat grafts can be performed. This study aimed through the presentation of clinical cases to suggest a therapeutic plan comprised of two sequential treatments: aquisition of platelet gel from a small volume of blood (9 ml) followed by the Coleman technique for reconstructing the three-dimensional projection of the face contour, restoring the superficial density of the facial tissues. The results obtained prove the efficacy of these two treatments combined, and the satisfaction of the patient confirms the quality of the results. READ MORE

Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients.

BACKGROUND: Platelet-rich plasma (PRP) has long been known as an effective treatment in various surgical and medical fields. Face and neck revitalization with PRP is an application that is currently being explored. The aim of this paper is practical: to evaluate if there are real outcomes, benefits and side effects of a standardized injection protocol in a continuous series, without control groups.

MATERIALS AND METHODS: In a three-month study, a consecutive series of 23 patients were treated with one session of injections with PRP every month from September 2008 to December 2008 (a total of three sessions). For blood management, a sterile Regen Lab Kit was used. Patients received 4 mL of PRP, activated with calcium chloride, at standard injection points into face and neck skin. The study was documented with imaging before and after each session using a dermoscope, a digital camera, as well as a comprehensive state-of-the-art imaging system and dedicated medical imaging software.

RESULTS: The results were evaluated one month after the last session (January 2009) by a special spider improvement score, a photograph score, a patient’s satisfaction score and a doctor’s satisfaction score. Finally, a definitive graduated score was calculated for each patient. Overall, the results were satisfactory. No serious and persistent side effects were detected.

CONCLUSION: Face and neck revitalization with PRP is a promising easy-to-perform technique in face and neck rejuvenation and scar attenuation. Further work needs to be carried out to investigate its exact mechanism of action. READ MORE

Induction of Dermal Collagenesis, Angiogenesis, and Adipogenesis in Human Skin by Injection of Platelet-Rich Fibrin Matrix

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome, is an uncommon degenerative and poorly understood condition. It is characterized by a slow and progressive atrophy affecting one side of the face.

The incidence and cause of this alteration are unknown, and the pathogenesis of the syndrome is not clear. Some authors attribute the atrophy of the subcutaneous system to an alteration of the sympathetic system. Others attribute it to an alteration of the nervous system at the encephalic level or to an interstitial neuritis of the trigeminal nerve. The most common complications that appear in association with this disorder are trigeminal neuritis, facial disorders, and epilepsy. The latter is the most frequent complication of the central nervous system. Characteristically, the atrophy progresses slowly for several years and soon becomes stable. After stabilization of the disease, plastic surgery of autogenous fat grafts can be performed. This study aimed through the presentation of clinical cases to suggest a therapeutic plan comprised of two sequential treatments: aquisition of platelet gel from a small volume of blood (9 ml) followed by the Coleman technique for reconstructing the three-dimensional projection of the face contour, restoring the superficial density of the facial tissues.

The results obtained prove the efficacy of these two treatments combined, and the satisfaction of the patient confirms the quality of the results. READ MORE

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